Metabolism of Pentachlorophenol in Mammals

Lysine metabolism in mammals.

The enzymes involved in the initial degradative steps of lysine metabolism, lysine-2-oxoglutarate reductase and saccharopine dehydrogenase, were studied and their activities in different mammals compared. Values obtained in human, rat, pig, dog, cat, ox and sheep liver indicated that in vitro, appreciable degradation of lysine to saccharopine (4-6nmol/min per mg of protein) occurred. The specif...

Nicotinamide metabolism in mammals.

Effect of pentachlorophenol on hepatic glycogen metabolism in rats.

Pentachlorophenol (PCP) is widely used as a biocide, although, its usage is limited to restricted regions in Japan because of its strong toxicity to fishes. With regard to the biochemical aspects of PCP toxicity, Weinbach1) found that PCP inhibited oxidative phosphorylation in vitro and postulated that the inhibition was at least partly responsible for the toxic effects of PCP. Since then, bioc...

Mathematical modeling of polyamine metabolism in mammals.

Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, and its deregulation is involved in relevant processes, such as cancer and neurodegenerative disorders. Great efforts have been made to elucidate the nature of polyamine homeos...

An Overview of Sex Selection at Conception in Mammals

Although the mechanisms under which sex ratio is controlled in nature remain unknown, researchers have attempted to treat sperm in an effort to predetermine the sex of the offspring. The methods of sperm separation that have been repeatedly reported to isolate fractions rich in X- or Y-chromosome bearing sperm are serum albumin gradient swim-up and flow cytometry. However, the ability of the se...